Featuring articles on a monoclonal antibody to prevent malaria infection, monoclonal antibody therapy in Parkinson’s disease, and dulaglutide in youths with type 2 diabetes; a review article on spina bifida; a Clinical Problem-Solving on diagnostic aspirations; and Perspective articles on building a national public health system in the U.S., on a preview of the dangerous future of abortion bans, on the end of Roe v. Wade, and on code words.

NEJM This Week — August 4, 2022

Featuring articles on supplemental vitamin D and incident fractures, brentuximab vedotin in advanced Hodgkin’s lymphoma, litifilimab for cutaneous lupus erythematosus, genetic protection against liver disease, and on lawmakers v. the scientific realities of human reproduction; a review article on tobacco addiction; a case report of a man with hypoglycemia; and Perspective articles on the history of health law in the United States, on primary care and financial risk, and on achieving the Triple Aim for sexual and gender minorities.

NEJM This Week — July 28, 2022

Featuring articles on tirzepatide for weight loss in adults with obesity, pembrolizumab in triple-negative breast cancer, Covid-19 vaccination in children 5 to 11 years of age, and gene therapy for hemophilia B; a review article on obesity in pregnancy; a case report of a woman with cavitary lung lesions; and Perspective articles on communicating statistics on climate change, on Medical Device User Fee reauthorization, and on grieving in a pandemic.

NEJM This Week — July 21, 2022

Featuring articles on maternal vaccination and Covid-19 among infants, adagrasib in KRASG12C-mutated lung cancer, continuous maintenance therapy in myeloma, and erythropoietin for hypoxic–ischemic encephalopathy in newborns; a review article on breakthrough hemolysis after complement inhibition; a case report of a girl with fever and cough; and Perspective articles on moving from regressive toward progressive value-based payment, on expanding accountable care among Medicare beneficiaries, on Russia’s war in Ukraine, and on tackling implicit bias in health care.

NEJM This Week — July 14, 2022

Featuring articles on trastuzumab deruxtecan in HER2-low breast cancer, effects of previous infection and vaccination on symptomatic omicron infections, and a report on porcine-to-human cardiac transplantation; review articles on pulmonary embolism and on the vaccine-hesitant moment; a Clinical Problem-Solving on the young and the breathless; and Perspective articles on physicians spreading misinformation on social media, on dietary supplements and institutionalizing misinformation, and on the portal.

NEJM This Week — July 7, 2022

Featuring articles on restricted intravenous fluid in septic shock, an oncolytic virus for pediatric pontine glioma, ibrutinib for untreated mantle-cell lymphoma, and on the potency of a KRAS silent variant; a review article on mantle-cell lymphoma; a case report of a man with vision changes; and Perspective articles on nineteen days in America, on a comprehensive Covid-19 response, on the solution shop and the production line, and on being without question.

NEJM This Week — June 30, 2022

Featuring articles on PD-1 blockade in locally advanced rectal cancer, a vaccine against respiratory syncytial virus, a vitamin C infusion in adults with sepsis, and reducing administrative harm in medicine; a review article on Philadelphia chromosome–positive acute lymphoblastic leukemia; a case report of a woman with jaundice and chronic diarrhea; and Perspective articles on racial disparities in breast-cancer mortality, on enrollee premiums in Medicaid, on a data infrastructure for clinical trial diversity, on medicalizing the Constitution, and on unexpected closure.

NEJM This Week — June 23, 2022

Featuring articles on circulating tumor DNA and adjuvant therapy in colon cancer, the prevention of anal cancer, Chapare hemorrhagic fever in Bolivia, immune tolerance after sequential stem-cell and kidney transplantation, and potentiating the T cell; a review article on climate change, fossil-fuel pollution, and children’s health; a case report of a woman with recurrent fractures; and Perspective articles on research to move policy, on climate change in the Supreme Court, and on medical readers and literary plague.

NEJM This Week — June 16, 2022

Featuring articles on chronic traumatic encephalopathy in military personnel, a PDE4 inhibitor for idiopathic pulmonary fibrosis, a monoclonal-antibody combination to prevent Covid-19, natural and hybrid immunity to SARS-CoV-2, and emerging technologies in health and medicine; a review article on the diagnosis and treatment of frostbite; a case report of a boy with chest pain; and Perspective articles on a radical treatment for insulin pricing, on the tobacco wars’ lessons for the vaccination wars, on physicians as political pawns, and on the high cost of cancer drugs under Medicare Part D.

NEJM This Week — June 9, 2022

Featuring articles on an albuterol–budesonide rescue inhaler in asthma, the efficacy of a plant-based SARS-CoV-2 vaccine, the efficacy and safety of a spike protein subunit vaccine, and neoantigen T-cell receptor gene therapy in pancreatic cancer; a review article on the uses of a GFR and albuminuria level in kidney disease; a Clinical Problem-Solving describing the after-dinner dip; and Perspective articles on navigating the loss of abortion services, on HIV prevention and the 340B Drug Pricing Program, and on the care and treatment of black girls in America.

NEJM This Week — June 2, 2022

Featuring articles on neoadjuvant chemoimmunotherapy in resectable non–small-cell lung cancer, tranexamic acid for noncardiac surgery, activation of oncogene expression by demethylating agents, efficacy of the mRNA-1273 vaccine in older children, and structural racism in the academic residency clinic; a review article on the gliflozins in the management of cardiovascular disease; a case report of a man with fevers, night sweats, and a mediastinal mass; and Perspective articles on federal action supporting overdose-prevention centers, on when naloxone isn’t enough, and on e pluribus unum.

NEJM This Week — May 26, 2022

Featuring articles on childhood risk factors and adult cardiovascular events, results of two cases of pig-to-human kidney xenotransplantation, vaccine effectiveness against omicron in children and adolescents, the efficacy and safety of a BNT162b2 booster, catching up on REMs, and on NEJM Healer; a review article on brain tumors in children; a case report of a man with persistent cough and pulmonary opacities; and Perspective articles on reforming nursing home care, on progress toward pig-to-human xenotransplantation, and on being only halfway there with sudden infant death syndrome.

NEJM This Week — May 19, 2022

Featuring articles on the treatment of mild chronic hypertension during pregnancy, lenacapavir for HIV-1 treatment, booster vaccination against omicron in Qatar, and on reframing the quality question; a review article on preeclampsia; a case report of a man with chylous ascites; and Perspective articles on health care reform under the Biden administration, on supporting innovation in Medicaid policy, and on unmuting.

NEJM This Week — Audio Summaries

NEJM This Week — Audio Summaries

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