Episode #281. With nearly a quarter of the world's population estimated to be affected by non-alcoholic fatty liver disease (NAFLD), understanding its intricacies is crucial. Join me as Dr Alan Flanagan helps unravel the complexities of NAFLD, breaks down its wider health ramifications, and offers insights on managing and living with the condition.

We discuss:

Introduction to Fatty Liver Disease (00:00)

Understanding Non-Alcoholic Fatty Liver Disease and Its Development (02:27)

Risk Factors: Gender Differences in Fatty Liver Disease Development (09:33)

The Science of Hepatic Fat Oxidation (14:45)

Consequences and Effects of Fatty Liver Disease (20:25)

Identifying Symptoms of Non-Alcoholic Fatty Liver Disease (25:54)

Risk Assessment: Non-Alcoholic Fatty Liver Disease in Premenopausal Women (29:33)

Energy Toxicity and Misconceptions about BMI (34:50)

Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes (48:34)

Liver Changes During Non-Alcoholic Fatty Liver Disease Progression (1:02:16)

Strategies for Reducing Fat Accumulation in the Liver (1:05:28)

The Role of Time-Restricted Eating in Managing Fatty Liver Disease (1:11:41)

The Impact of Sugars on Fatty Liver Disease (1:20:16)

Understanding the Relationship Between Dietary Fats and Fatty Liver Disease (1:41:16)

High Saturated Fat Diets and Their Effect on Fatty Liver Disease (1:57:19)

Importance of Caloric Source Variation in Dietary Fats (1:59:23)

Beneficial Dietary Patterns for Liver Health (2:04:07)

Analysing Dairy Types and Their Effects on Liver Fat (2:08:29)

Meal Frequency and Its Relation to Liver Fat Accumulation (2:12:40)

Recommended Lifestyle Changes for Preventing Non-Alcoholic Fatty Liver Disease (2:17:59)

Conclusion: Key Takeaways on Fatty Liver Disease Management (2:20:07)


Connect with Alan Flanagan on Instagram, and learn more about his company, Alinea Nutrition, here. Make sure to listen to his five previous appearances on The Proof here.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Protect your liver and promote optimal metabolic health | Alan Flanagan, PhD

Episode #280. Ever wondered how the simple act of timing – when you eat, sleep, or even look at your phone – could dramatically affect your health? In this episode, I sit down with circadian biology expert Dr Satchin Panda to explore this concept. We delve into the science of our body's internal clocks and offer practical advice to keep them in sync. Don't miss out on unlocking the potential of your circadian rhythm for a healthier, more balanced life.

We discuss:

Introduction (0:00)

Understanding Circadian Rhythms: Do They Influence Longevity? (1:55)

The Role of the Suprachiasmatic Nucleus (SCN) in Circadian Rhythms (6:20)

Cellular-Level Circadian Clocks: An Overview (10:33)

A Comprehensive Look at Circadian Disruption (15:56)

Effective Strategies for Managing Jet Lag (26:39)

The Impact of Blue Light on Circadian Rhythms (29:17)

Criteria for Diagnosing Circadian Rhythm Disorders (33:42)

Sensitivity Factors of Circadian Rhythms (34:58)

The Significance of Meal Timing in Circadian Rhythms (39:30)

Circadian Rhythms: Their Relation to Cholesterol and Blood Pressure (43:41)

Exploring the Link Between Circadian Disruption, DNA Damage, and Cancer Risk (46:49)

Circadian Disruption and Its Role in Chronic Disease Risk (49:34)

Time-Restricted Eating and Metabolic Health (55:22)

Outro (1:06:09)


To connect with Dr Satchin Panda, you can find him on Twitter and read his peer-reviewed papers on his profile. To learn more about circadian biology, his books, The Circadian Code and The Circadian Diabetes Code, are an incredible resource. You can also better understand your circadian rhythm while contributing to research with Dr Panda’s app, myCircadianClock.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Neglecting our body's natural clocks is harming our health (Part 1)  | Satchin Panda, PhD

Episode #279. You've heard a lot about the benefits of Zone 2 training, but how do you actually fit it into your busy schedule? Join me as I sit down with exercise physiologist Drew Harrisberg to dive into the practical aspects of implementing Zone 2 training.
Drew brings both professional insight and personal experience to help you understand how to optimise your training zones for long-term health benefits. Tune in to learn how to get the most out of your workouts, backed by science and sprinkled with good laughs.

Specifically, we discuss:

Intro (00:00)

Drew's Insights on Training Regimens (06:52)

Deep Dive with Inigo: Exploring Zone 2 Training (09:01)

The Importance of Mitochondrial Function in Workout Planning (22:38)

Do You Really Need 300 Minutes in Zone 2? (23:56)

Discovering the Ideal Cardio Protocol (31:10)

Cardio Strategies on Social Media: Are They Effective? (40:51)

Methods to Accurately Measure Your Maximum Heart Rate (46:34)

The Perfect Cardio Routine: Part II (50:46)

Unveiling the Truth: Latest Research on the Fat-Burning Zone (1:02:40)

Dad Joke of the Week (1:13:48)

Navigating Science-Backed Information on Social Media Platforms (1:15:02)

Shedding Light on Visceral Fat and Its Implications (1:19:14)

Tailored Diets: Are They the Answer to Individualised Nutrition? (1:26:08)

The Controversy Surrounding Seed Oils (1:33:02)

Outro (1:36:56)


To connect with Drew, you can reach him via his Instagram or website, Drew’s Daily Dose. He also has a training program to put many of the principles discussed today and in previous episodes into practice. Find Drew’s many previous episodes on *The Proof* website.
Make sure to check out the full show notes, where you’ll find additional insights, guidance on calculating your max heart rate and zones, and a three-day a week training program.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary
Two-Week Meal Plan and high protein Plant Performance recipe book

Zone 2 takeaways and an evidence-based 3 day cardio program for longevity | Drew Harrisberg, BSc

Episode #278. If you follow a plant-based diet, chances are you’ve wondered if you’re getting an adequate amount of omega-3. Join me as I sit down with Professor Philip Calder, an international authority in nutritional immunology with over 20 years of research on fatty acids.
Professor Calder helps to cut through the confusion to give you the science-backed breakdown on how these fats impact your health, and how much you should really be consuming. Learn everything you need to know about these essential fats in your diet in this episode.

Specifically, we discuss:

Introduction (00:00)

Philip Calder&#39;s Passion for Fatty Acids and His Background (02:00)

Debunking Major Fatty Acid Myths in Academia &amp; Social Media (05:53)

Altering Cell Membrane Health Through Diet (11:14)

Understanding Essential Fats: Why are They Vital? (13:57)

Low Conversion Rates: From ALA to EPA &amp; DHA Explained (18:08)

The Importance of Monitoring Omega 6 Intake (23:31)

The Link Between Omega 6 Fatty Acids and Inflammation (27:28)

Does Dietary Linoleic Acid Impact Arachidonic Acid? (35:23)

The Inflammatory Role of Arachidonic Acid (37:29)

Linoleic Acid &amp; Its Inflammatory Effects (40:41)

Should Western Diet Adopters Reduce Omega 6 Intake? (43:56)

Major Omega 6 Food Sources and Their Alternatives (45:58)

Balancing Omega 3 &amp; Omega 6: Impact on Inflammation (48:57)

Plant-Based EPA &amp; DHA: The Genetic Modification Approach (52:04)

The Health Implications of Replacing Saturated Fat with Linoleic Acid (59:24)

Cardiometabolic Risks of Polyunsaturated Fats (1:03:55)

How Omega 3 &amp; Omega 6 Influence Insulin Resistance (1:07:17)

Polyunsaturated Fats&#39; Effect on Blood Pressure (1:08:31)

The Long-Term Impact of Consuming Polyunsaturated Fats (1:12:05)

EPA &amp; DHA Research Variance: Doses, Types, and Outcomes (1:15:40)

Ideal Omega 3 Levels for General Health (1:21:51)

Benefits of Plant-Based EPA &amp; DHA Supplements (1:27:55)

Concerns with Low ALA Levels (1:30:17)

Absorption Efficiency of EPA &amp; DHA Supplements (1:32:34)

The Science Behind Omega 3 Testing (1:34:28)

Algae Oil vs Fish Oil: Which is Superior? (1:36:36)

DPA Supplementation and Its Benefits (1:38:33)

Does DHA &amp; EPA Supplementation Impact Cholesterol Levels? (1:40:34)

Potential Side Effects of DHA &amp; EPA Supplements (1:42:03)

Conclusion (1:45:44)


Learn more about Professor Philip Calder and his work at southampton.ac.uk/people/5wzh2r/professor-philip-calder.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podca

What you need to know about omega 3 and 6 fats | Philip Calder, PhD

Episode #277. Curious about the buzz around Zone 2 training? Dr Inigo San Millan, an expert in metabolic health and sports performance, joins me to decode the science behind Zone 2. Learn how to fine-tune your exercise intensity for metabolic flexibility, longevity, and peak performance.

We discuss:

Introduction (00:00)

Understanding Metabolic Health (2:21)

Metabolic Health Among Elite Athletes: Exploring the Perfection of Studying (6:40)

Metabolic Health, Mitochondria, and Nutrition (8:00)

Defining &#39;Metabolise&#39; (14:41)

Exploring Metabolic Flexibility (18:33)

Determining the Causes of Mitochondrial Dysfunction (21:01)

The Role of Oxygen in Energy Production Mechanisms (24:44)

Comprehending Energy Zones (28:07)

Energy Metabolism Mechanisms: Glucose vs. Fat (40:27)

Zone 2&#39;s Optimal Stimulation of Mitochondria (45:29)

Lactate&#39;s Impact on Mitochondria: Unraveling the Effects (50:46)

Managing Lactate Levels: Strategies Employed by Athletes (59:37)

Establishing an Aerobic Base (1:15:13)

Inducing Mitochondrial Stimulation Through Zone 2 Training (1:17:31)

Strategies for Enhancing Mitochondrial Count (1:19:27)

Carbohydrates&#39; Influence on Metabolic Health (1:29:26)

Metabolic Health in Sedentary Lifestyles: Understanding the Impact (1:31:04)

Zone 2 Demystified: Unveiling Its Significance (1:37:59)

Recognizing Zone 2: How to Identify Your State (1:39:57)

Monitoring ATP Production Fuel via Specialized Devices (1:49:12)

Zone 2&#39;s Role in Fat Loss: Separating Fact from Fiction (1:53:49)

Optimizing Zone 2 Intensity for Maximum Results (1:59:59)

Weekly Zone 2 Prescription for Robust Mitochondrial Health (2:07:24)

Effective Modalities for Zone 2 Training: Making Informed Choices (2:11:50)

Resistance Training&#39;s Integration within Zone 2 Regimen (2:18:11)

The Optimal Timing for Zone 2 Training: Navigating the Day (2:20:29)

Supplements and Their Relevance to Zone 2 (2:26:17)

Summarizing the Essence of Zone 2 (2:35:06)

Amplifying Training Benefits: Embracing Zones 3 and 4 (2:38:17)

Outro (2:40:04)


Connect with Dr Inigo San Millan on Instagram and Twitter/X. If you’d like to listen to the episode with Dr Herman Pontzer that we mentioned in this conversation, you can do so here.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a 20% discount at insidetracker.com/simon.
For more insights and supporting studies, visit The Proof website for the full show notes.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is

Science of zone 2 cardiovascular exercise (Part 1) | Inigo San Millan, PhD

Episode #276. How does an earth scientist embark on a career journey that traverses the fossil fuel industry, Silicon Valley alongside Steve Jobs, and a mission to revolutionise our approach to food?
Chris MacAskill has worn many hats throughout his career, overcoming extreme hardship to get to where he is today. This episode challenges conventional thinking and is an inspiration to more carefully consider the choices we make every day, both for our health and the planet.

We discuss:

Introduction (00:00)

Insights into Chris MacAskill's Background (03:00)

Ancell Kees' Studies (07:20)

Chris MacAskill's Childhood (13:50)

Life-Altering Experiences of an Earth Scientist (32:51)

Climate Change in the 1980s (40:01)

Fuel Companies: Lobbying and Financing (43:39)

Obesity, Public Healthcare, and Public Interest (46:33)

A Deep Dive into Various Diets with Chris MacAskill (50:42)

Diets Preferred by Brain Scientists (1:04:53)

Understanding the Impact of Food on the Environment (1:08:46)

The Health Implications of Beef Consumption (1:15:09)

An Introduction to Cellular Agriculture (1:19:50)

National Geographic Documentary Films & General Magic (1:23:48)

Working Alongside Steve Jobs (1:35:41)

The Legacy of General Magic (1:48:02)

The Computer History Museum (2:01:01)

Missfits (2:02:06)

Transforming Weaknesses into Superpowers (2:07:43)

How to Choose the Right Nutrition Expert to Listen to? (2:13:59)

The Future of Plant Chompers (2:22:07)

Outro (2:28:30)


Connect
Discover Chris MacAskill’s work on his Plant Chompers YouTube channel, where you’ll find accessible, research-backed educational content. You can also connect with him on Instagram, Twitter, and LinkedIn.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
For more insights and dozens of additional resources, head to the full show notes on The Proof website.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Silicon Valley entrepreneur on eating for the planet | Earth scientist Chris MacAskill

Episode #275. Have you ever wondered how your gut health might affect your body weight? In this episode, I sit down with Dr Will Bulsiewicz – a leading authority in gut health and The Proof fan favourite – to unravel the fascinating connection between the microbiome and metabolism.
From exploring dietary fibre’s impact on disease prevention to comparing ketogenic and plant-based diets, this conversation offers a deep dive into how our inner ecosystem influences our overall health. Tune in for actionable insights and scientific revelations that could transform your approach to wellbeing.

Specifically, we discuss:

Intro (00:00)

Introduction to Dr. Will Bulsiewicz and His Literary Contributions (2:42)

Do Gastroenterologists Analyse Their Own Stool? (7:43)

Dr. Will Bulsiewicz&#39;s Collaboration with ZOE (9:55)

Behind the Scenes: Dr. Will&#39;s Nutritional Supplement Venture (11:20)

The Progressive Journey of the Gut Health Movement (14:02)

Decoding the Microbiome: Its Role and Significance in Health (17:20)

Exploring Metabolism and Metabolic Health (0:24:50)

The Microbiome&#39;s Role in Influencing Metabolism (0:33:07)

Understanding GLP-1 Agonists: Their Impact on Satiety and Weight Reduction (0:38:54)

Tips to Increase Dietary Fibre Intake for Better Health (0:45:05)

The Connection Between Microbiome and Fat Metabolism (0:47:36)

Strategies to Boost Metabolism and Promote Brown Fat Activation (0:49:59)

The Role of Lipopolysaccharide in Gut Barrier Functionality (0:51:33)

Significance of Gut Health and the Risks of Dysbiosis (0:54:49)

Linking Insulin Resistance with Satiety Mechanisms (0:56:03)

The Relationship Between Satiety and Blood Sugar Fluctuations (0:58:30)

Analysing Kevin Hall&#39;s Research: Plant-Based Diet vs. Alternative Diets (1:02:04)

Blood Regulation, Insulin Resistance, Lipotoxicity, and Microbiome (1:10:38)

Deciphering Glucose Homeostasis: What You Need to Know (1:20:37)

The Interplay Between Insulin Resistance and Obesity Factors (1:21:51)

The Beneficial Role of Dietary Fibre in Blood Sugar Management (1:23:11)

Is Reversing Type 2 Diabetes a Possibility? (1:25:18)

How the Microbiome Influences Blood Sugar Regulation Mechanisms (1:32:12)

The Cholesterol-Lowering Benefits of Dietary Fibre (1:37:06)

Top Sources of Soluble Fibre for a Healthy Diet (1:39:40)

Triglycerides and Their Relationship with the Microbiome (1:42:06)

The Protective Role of Fibre in Disease Prevention (1:46:28)

Outro (1:51:46)


Connect with Dr Will Bulsiewicz on Instagram, Facebook, Twitter, and TikTok. Discover more resources and Dr B’s books on his website, theplantfedgut.com, learn more about supplementation at 38tera.com, and find his work on personalised nutrition at joinzoe.com. Listen to Dr B’s past appearances on The Proof here.
My team and I have also put together a PDF of resources for this episode, helping you better understand the science behind this conversation. Download it at theproof.com/drb.
Optimi

How the microbiome affects metabolism and body weight  | Dr Will Bulsiewicz, MD

Episode #274. Join me as I sit down with Dr Joel Fuhrman to explore the Nutritarian diet, a unique approach that emphasises nutritional excellence to prevent cancer, slow aging, and even reverse chronic disease.
With insights into reversing chronic illnesses and understanding the balance between caloric and nutrient satisfaction, Dr Fuhrman&#39;s perspective offers a fresh take on nutrition. Tune in for a valuable exploration of food as medicine and learn practical strategies to optimise your wellbeing through food choices.

Specifically, we discuss:

Introduction to Dr Joel Fuhrman and the Nutritarian Lifestyle (00:00)

Overview of Dr Fuhrman&#39;s Micronutrient-rich Diet and Its Advantages (2:43)

The Role of Fibre and Resistant Starch in Diet (9:32)

Dr Fuhrman&#39;s Personal Introduction to Plant-based Eating (12:08)

The Importance of Optimising Omega-3 Consumption (22:42)

Understanding DHA and EPA: Do we need them (28:03)

Blue Zones (33:33)

The Role of Zinc in Diet and When to Think About Supplementation (37:55)

A Detailed Examination of the Nutritarian Diet and Its Benefits (43:42)

Oils: What do you need to know? (52:27)

Comparing Plant-based Proteins to Animal Proteins (58:21)

Aligning Protein Consumption with Exercise for Longevity (1:05:09)

The Dietary Debate: Plant-sourced vs. Animal-sourced Low-Carb Diets (1:14:30)

Addressing Autoimmune Conditions Via Diet (1:18:30)

The Influence of Diet on Weight Reduction and Reversing Chronic Illnesses (1:22:03)

The Challenge of Educating and Modifying Dietary Behaviours (1:31:33)

Overweight and fat distribution (1:35:12)

How Weight Reduction Can Be Revolutionary in Reversing Diabetes (1:40:21)

The Link Between Sleep Patterns and Eating Schedule (1:46:59)

Strategic Eating: Maximising Gains from Vegetables, Nuts, Seeds, and Soups (1:47:52)

Underlining Collective Effort for a Healthier Society (1:53:58)

Outro (1:56:59)


Learn more about Dr Joel Fuhrman and his work at https://www.drfuhrman.com/, where you’ll find resources and opportunities for personalised guidance. You can also connect with him on Instagram, Twitter , Facebook, and YouTube.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Make sure to head to The Proof website for the full show notes and supporting studies.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram,

Achieving Longevity and Healing through Food: A Deep Dive | Dr. Joel Fuhrman, Md

Episode #273. When we think about health and wellness, what usually comes to mind is nutrition, exercise, sleep, or some other tangible metric. But what about love? In this conversation, I sit down with relationship coach Jillian Turecki to hear her insights on the power of a healthy relationship.

We discuss:

Intro (00:00)

Quality of self-love = quality of love life (2:25)

Red flags, compatibility, and being "perfect" (7:50)

Self-worth and personal responsibility (15:49)

Practices for nurturing self-love (24:45)

Confidence is key (29:41)

Dating and more red flags (36:46)

Societal pressures (45:15)

Lust and love (51:48)

Romantic relationship and loneliness (54:55)

What about getting dates in the first place? (59:04)

Honesty is king (1:08:56)

Declining of marriage rates (1:12:21)

Lasting love amidst flaws and imperfections (1:16:38)

Attachment styles (1:21:20)

Foundation of a successful relationship (1:28:14)

Supportive relationship, sex, and stress (1:31:33)\

Porn (1:37:33)

Communication mistakes and benefits of therapy (1:42:44)

Monogamy and 'alternative' relationships (1:54:13)

Why happy relationships lead to longer, healthier lives (2:01:05)

Jillian on marriage and motherhood (2:03:56)

Outro (2:05:04)


Connect with Jillian Turecki on Instagram, Twitter, and TikTok. Visit Jillian’s website to discover more about her work and discover her courses. Make sure to also check out her podcast, Jillian On Love.
Make sure to visit The Proof website for the full show notes.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

Dating, sex, marriage and relationship building | Jillian Turecki

Episode #272. In the quest for an extended lifespan, has science been led astray? Join me as I sit down with Professor Charles Brenner, a leading global expert in NAD biology, to examine the longevity field's claims and controversies.
From debunking common beliefs to questioning high-profile opinions, Dr Brenner delivers a refreshingly candid perspective on the science of aging. Tune in to explore why he believes there's no “cure” for aging, the limitations of animal studies, and what the future might hold for this complex field.

Specifically, we discuss:

Intro (00:00)

Do we have the genes to live beyond 120 years? (3:54)

The genetics of extreme longevity (14:18)

Longevity in the animal kingdom (18:26)

Why do we age, and the realities of extending lifespan (31:22)

How long can we live? (39:01)

NAD coenzymes and DNA repair (43:49)

"Anti-ageing" products (55:17)

Conflicts of interest and the integrity of scientific claims (1:01:08)

Discovering nicotinamide riboside (NR) (vitamin B3) (1:03:19)

Sirtuins as anti-ageing genes (1:09:22)

A rebuttal to Drs. David Sinclair and Lenny Guarente (1:19:13)

Seeking consensus on the study of human longevity (1:32:57)

The information theory of aging (1:43:19)

Dr. Charles Brenner's theory of ageing (2:00:28)

How to age better (2:03:30)

Dr. Brenner on the quality of life (2:09:05)

NR supplementation (2:10:09)

Moving beyond Yamanaka factors (2:15:02)

Outro (2:18:45)


Connect with Dr Charles Brenner on Twitter, and visit his website, https://www.brennerlab.net/, for more.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Is longevity science overhyped? | Professor Charles Brenner, PhD

Episode #271. Have you ever wondered just how much of an effect antibiotics have on your health? Gastroenterologist and gut health expert Dr Will Bulsiewicz returns to the show in this episode, breaking down how antibiotics impact our microbiome and the steps you can take to protect and restore your gut health before, during, and after taking them.

Specifically, we discuss:

Intro (00:00)

What are antibiotics? (03:01)

Efficacy, prescription, and 'antibiotic scar' (08:26)

The healthy gut microbiome (15:58)

Effects of antibiotics to gut the microbiome (21:32)

Clostridioides difficile (28:30)

Do you really need antibiotics? (31:04)

High-fibre diet (39:44)

Sprouts, lentils, and fermented foods (43:25)

Prebiotics and prebiotic supplements (46:30)

Probiotics and microbiome recovery after antibiotics (58:06)

Who may benefit from taking probiotics? (1:05:00)

Foods to limit to avoid dysbiosis (1:07:45)

Why do antibiotics cause yeast infections? Do probiotics help? (1:09:35)

Antibiotics and small intestinal bacterial overgrowth (SIBO) (1:11:04)

Lifestyle changes to boost microbiome recovery after taking antibiotics (1:13:49)

Outro (1:18:56)


Connect with Dr Will Bulsiewicz on Instagram, Facebook, Twitter, and TikTok. Discover more resources and Dr B’s books on his website, theplantfedgut.com, and learn more about supplementation at 38tera.com. Listen to Dr B’s past appearances on The Proof here.
My team and I have also put together a PDF of resources for this episode, helping you better understand the science behind this conversation. Download it at theproof.com/drb.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

How to heal your microbiome after antibiotics | Dr Will Bulsiewicz, MD

Episode #270. If you’ve ever been confused by the sea of women’s health misinformation, you’re not alone. Join me as I sit down with Dr Jen Gunter, internationally celebrated OB/GYN and New York Times bestselling author, to dispel disinformation with evidence.
We address everything from yeast infections to birth control, compounded hormones, and menopausal hormone therapy. This isn’t just a health masterclass, but also a critical conversation about the misinformation and disinformation that is pervasive in women's health discussions: essential listening for anyone who cares about promoting an equitable health landscape.

Specifically, we discuss:

Intro (00:00)

Dr. Jen Gunter on Gynecology (2:56)

Misinformation vs disinformation (8:11)

Western medicine and the truth about supplements (15:16)

Tips for discerning online information (20:43)

Yeast infection and how to really treat it (29:42)

Can diet treat yeast infection? (38:04)

Is a vaginal microbiome test necessary? (44:52)

Understanding menstruation and contraception (47:47)

Challenges for women in their mid-30s after birth control (54:00)

Menopause, hormone testing, and symptom assessment (1:01:42)

The grandmother hypothesis (1:07:13)

Hormone therapy (1:10:32)

Bioidentical hormones vs. what's recommended (1:18:02)

Alternative treatments for hot flashes (1:26:52)

What men need to know and how they can help (1:32:42)

Outro (1:39:38)



Connect with Dr Jen Gunter on Instagram, Twitter, and TikTok. For more comprehensive information, you can read Dr Gunter’s two books, The Vagina Bible and The Menopause Manifesto. Head to her blog, https://vajenda.substack.com/, for frequent newsletters and articles.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Looking for more episodes centred around women’s health? Listen to past episodes on this topic here.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary
Two-Week Meal Plan and high protein Plant Performance recipe book

Women’s health misinformation | Dr Jen Gunter, OB, GYN

Episode #269. Dive into the heart of controversial nutrition studies and discover the surprising complexities behind everyday food choices with Professor Gardner, a respected authority in the field of nutrition science.
As we navigate the maze of dietary patterns, this insightful conversation bridges the gap between scientific evidence and practical nutrition, empowering you to make informed decisions about your health.

We discuss:

Intro (00:00)

A twin study is in the works (4:06)

Plant-based meat vs. red meat (8:53)

How to make homemade kombucha (18: 40)

Different diets for athletic performance (the SWAP-MEAT trial) (23:02)

Feedback from athletes (37:21)

Which popular diets are truly heart-healthy? (40:35)

How different diets measure up to health guidelines (49:12)

Practical insights for doctors and patients (55:07)

The truth about low fat, vegan diet (59:36)

Controversies vs consensus in nutrition (1:02:45)

The food industry and medical institutions (1:10:19)

Low-fat & low-carb diets for weight loss (the DIETFITS study) (1:14:30)

Sustainable weight loss and GLP-1 agonists (1:28:25)

Psychological strategies to make veggies irresistible (1:36:00)

The “protein flip”, the academe, and a new book (1:46:09)

Outro (1:49:55)


Professor Gardner has also shared his homemade kombucha recipe with us. You can find it in this blog post.
Connect with Professor Christopher Gardner on Twitter. Head to https://nutrition.stanford.edu/ for more resources and studies, and the Stanford Nutrition YouTube channel for more videos. Listen to past episodes featuring Professor Gardner here.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

Nutrition for performance and a healthy heart | Professor Christopher Gardner, PhD

Episode #268. Ever felt overwhelmed by conflicting nutrition advice? In this episode, I sit down with Dr Matthew Nagra, a naturopathic doctor with a passion for plant-based nutrition. Together, we debunk common nutrition myths and bring clarity to some hot topics. Dr Nagra&#39;s evidence-based perspective will guide you through the noise, helping you make informed dietary decisions. From understanding biases to breaking down the facts about phytates and gluten, you’ll be better equipped to navigate the nutrition landscape with more clarity and confidence.

We discuss:

Intro (00:00)

Dr. Matthew Nagra&#39;s health journey (3:24)

The dangers of misinformation (7:49)

Does Matthew Nagra is biased vegan (11:39)

Dr. Matthew&#39;s approach to nutrition studies (15:00)

Does plants are trying to kill us? (18:42)

Does unprocessed red meat increase the risk of cancer and cardiovascular disease? (28:20)

Are Food Frequency Questionnaires reliable? (38:43)

Tucker Goodrich and the seed oil debate (40:16)

What oil you should use? (45:40)

Vegan diet and nutrient supplementation (48:00)

Precision fermentation (57:32)

Saturated fat, sodium, and fiber (1:01:39)

Fortified soy milk (1:10:36)

Do phytates and oxalates rob your body of minerals (1:15:23)

Is there a single optimal diet? (1:19:53)

Does eating fat make you fat? (1:22:17)

Do you burn more fat on a keto diet? (1:22:45)

Does a low-carb ketogenic diet is the best to treat type 2 diabetes (1:24:07)

Is low fat, vegan diet the optimal way to do a plant-based diet? (1:29:38)

Is low-fat vegan diet the best for cardiovascular health? (1:42:20)

Protein and resistance training (1:44:06)

Should you avoid gluten? (1:51:57)

Does Lectins cause a leaky gut? (1:53:42)

Outro (1:55:58)


You can connect with Dr Matthew Nagra on Instagram, Twitter, and Facebook. To learn more about Dr Nagra’s work and for other resources, head to his website, https://drmatthewnagra.com/. You can find his previous episodes here.
For more insights and dozens of supporting studies, visit The Proof website for the full show notes.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high-pro

Biggest myths in nutrition | Dr Matthew Nagra, ND

Episode #267. Join me for a deep dive into the influence of the gut microbiome on inflammation and metabolic disease. In this fascinating exchange with Dr Suzanne Devkota, we explore the role of the gut in these conditions, shedding light on food allergies, IBD, and obesity. You’ll learn the practical tips you need to nurture a healthy microbiome, as well as gain a better understanding of what we do – and don’t – know about this incredible system.

Specifically, we discuss:

Intro (00:00)

The evolving field of microbiome research (02:13)

Gut microbe on social media (09:32)

Microbiome definition (12:48)

Why the focus on gut bacteria? (13:55)

Differences in Microbes (16:02)

Microbial shifts and adaptations (18:45)

Microbes perturbations (21:35)

Human microbiome in evolution (23:54)

Healthy microbiome and diversity (27:47)

Is the microbiome the sole driver of metabolic diseases? (33:05)

Dietary patterns and FODMAP intolerance (41:07)

Saturated fat and gut health (49:15)

Microbiome metabolites and heart disease risk (57:42)

Inflammatory bowel disease (IBD) and dysbiosis (1:02:09)

Food additives (1:12:29)

Supporting the microbiome in IBD (1:15:29)

Microbiome's interaction with fat cells (1:16:52)

Short-chain fatty acids and appetite regulation (1:29:26)

Practical tips for nourishing a healthy gut (1:31:05)

Microbiome's interaction with Polyphenols (1:38:43)

On supplements and fermented foods (1:39:15)

Factors affecting gut health beyond nutrition (1:46:22)

Outro (1:50:10)


Connect with Dr Suzanne Devkota on Instagram and Twitter. Learn more about her research at http://www.devkotalab.com/thelab.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary
Two-Week Meal Plan and high protein Plant Performance recipe book

Gut microbiome in inflammatory and metabolic diseases  | Suzanne Devkota, PhD

Episode #266. Learn the key pillars for a healthy diet from the world’s most cited nutrition scientist, Dr Walter Willett. In this two-hour exchange, Dr Willett shares the cornerstones of a healthy diet, providing the practical guidance you need to live a long, healthy life.

We discuss:

Introduction (00:00)

Which Foods Should You Eat to Stay Healthy? (04:10)

Does the Quality of Foods Matter? (06:39)

The Impact of the Average American Diet on Health (08:29)

Do We Have Sufficient Evidence on How Nutrition Impacts Our Health? (11:05)

Key Tasks/Leaves to Make Healthy Choices (14:03)

How Diet Patterns Have Changed from the 70s till Now (15:09)

Walter Willet: A Nutrition Story (18:20)

Ancel Keys&#39; Research on Fat (19:40)

Three Large Observation Studies by Walter Willet and His Team (27:19)

Advantages of Large Observation Studies over Randomized Control Trials (32:45)

Correlation and Causation in Nutrition (39:15)

Food Frequency Questionnaire: Importance of Methods for Measuring Dietary Intake (50:58)

Biochemical Analysis in Three Cohort Observations of Walter Willet&#39;s Studies (55:18)

Are Low-Fat Diets Good for Cardiovascular Health? (1:00:37)

Polyunsaturated Fats and Cardiovascular Disease (1:02:21)

Benefits of Switching from Saturated Fat to Unsaturated Fats (1:08:31)

Is Dairy Bad or Good? (1:09:04)

Should You Consume Full-Fat or Low-Fat Dairy? (1:11:29)

Daily Recommendation for Dairy Consumption (1:16:03)

Can You Be Healthy Without Consuming Dairy? (1:20:42)

Confusion Surrounding Unprocessed Red Meat (1:23:00)

What is Substitution Analysis? (1:25:55)

Insights into the Research Process (1:27:45)

Contrast and Exposure in Research (1:29:33)

Safe Intake of Red Meat (1:33:02)

Is Grass-Fed Beef Good for Me? (1:33:51)

Is White Meat Better Than Red Meat? (1:35:57)

Fish vs. Legumes: A Comparison (1:36:37)

Dietary Cholesterol and Its Impact on Human Health (1:40:08)

The Best Diet for a Healthy Life (1:43:28)

Outro (1:52:01)


To learn more about Dr Walter Willett and read his studies, head to his Harvard Academic Profile. Dr Willett has also published four books; you can find his bestseller, Eat, Drink, and Be Healthy: The Harvard Medical School Guide to Healthy Eating here.
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instag

Mastering the Art of Healthy Eating:  Diet Tips and Nutrition Research | Professor Walter Willett, MD

Episode #265. Escaping an echo chamber and admitting that you have changed your mind ­– particularly when you have a large, engaged audience – is no easy feat. In this conversation, I sit down with Thomas DeLauer to break down some of the existing walls between different dietary camps, opening the conversation around nuance and an open-minded approach.

We cover:

Intro (00:00)

Simon makes assumptions about Thomas DeLauer (5:03)

Thomas on working out (6:58)

Biohacking (8:37)

Cold plunges and saunas (9:35)

Thomas DeLauer and alcohol (15:51)

Tea or coffee (18:50)

Battling and overcoming obesity (20:39)

Low-carb vs low-fat diet (31:06)

Unprocessed vs. ultra-processed diets (39:04)

Benefits of CGM for non-diabetic (47:10)

Saturated fat and insulin resistance (52:09)

What Thomas and Simon's diets look like (1:02:29)

Do we need fibre? (1:10:18)

Food intolerances (1:17:40)

Changing lifestyle after traumatic event (1:23:17)

Strategies for a healthier lifestyle (1:26:15)

Calorie Counting and Intermittent Fasting (1:28:26)

Thomas DeLauer on Vegan diet (1:35:46)

Choosing different diets and finding common ground (1:37:40)

Roy Taylor's research on Losing Weight (1:43:47)

How Sleep Deprivation affects your diet (1:51:01)

Outro (1:56:14)


For more insights like the ones shared in this episode, head to Thomas’ YouTube channel or check out his book, Intermittent Fasting Made Easy. You can also connect with him on Instagram and his website, https://thomasdelauer.com/.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Ditching diet dogma and why insulin isn’t the bad guy | Thomas DeLauer

Episode #264. Every day for more than 20 years, Adam Sud woke up to a life that didn’t feel like a safe, secure, or hopeful place to be. Struggling with mental health from an early age and relying on addiction as the only dependable “solution”, he spent years facing each day as the most painful one he’d ever had.
More than a decade on from the turning point in his journey towards recovery, Adam shares his story and some defining realisations that helped shaped the life he is now excited to experience.
Everyone has something to learn from Adam’s story. Regardless of whether you have personally struggled with addiction and mental health, Adam’s profound understanding of behaviour and mindset will resonate with you, and potentially even shift the way you look at your life.

Specifically, we discuss:

Intro (00:00)

Adam Sud on recovery (04:15)

Why expressing love can be difficult (08:55)

Substance use disorder (Drug addiction) (14:37)

Adam's story (16:46)

Nurturing a child with ADHD (24:42)

Becoming hooked on Adderall (32:41)

Understanding our choices for pleasure (36:09)

Addiction and the fear of judgment (41:00)

Adam's suicide attempt & his treatment and recovery (46:00)

Plant-based diet and the pleasure trap (1:02:21)

Psychological factors behind unhealthy choices (1:09:25)

Remarkable recovery through nutrition (1:18:29)

Self-worth, loneliness, and recovery (1:25:40)

A call for a safer and compassionate approach to drug use (1:31:56)

The INFINITE study (1:41:03)

Adam on hitting rock bottom (1:46:24)

Outro (1:53:46)


To connect with Adam Sud, you can find him on Instagram, Facebook, and LinkedIn. Don’t forget to visit his website, https://www.adamsud.com/, to learn more about Adam and read about The Infinite Study. Listen to Adam’s past appearances on The Proof in Episode #66 and Episode #144.
Please note that this episode covers disordered eating and suicide. If these topics are potential triggers for you, please listen with discretion or tune in to the next episode. You can find more episodes about mental health that focus less on personal experience here.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

Exploring drug addiction through story and science | Adam Sud

Episode #263. Delve into the complex world of neurodegenerative diseases in this evidence-loaded episode with Drs Dean and Ayesha Sherzai. Unpack the current scientific understanding of diseases like Alzheimer&#39;s and Parkinson&#39;s, bust popular food myths related to brain health, and discover actionable lifestyle tips for long-term brain health. Join us on this evidence-based journey that blends science with practical, real-life advice.

Specifically, we discuss:

Intro (00:00)

Drs. Ayesha and Dean play True or False (04:11)

Is amyloid plaque the primary cause of Alzheimer&#39;s? (05:47)

Whole grains, gluten, and brain health (07:11)

Artificial intelligence for Alzheimer&#39;s disease (14:11)

Drs. Ayesha and Dean on Melbourne (17:11)

Is olive oil good for brain health? (20:13)

What&#39;s the beef with red meat? (24:32)

Keeping the brain healthy with omega 3 fatty acids (35:25)

APOE4 and omega 3 supplementation (48:27)

Cognitive changes in midlife (54:47)

Reaction to Dr. Michael Klapper&#39;s U-turn on omega 3 supplementation (59:10)

Facts on choline (1:02:15)

Understanding neurodegenerative diseases (1:07:34)

Inheriting frontotemporal dementia: what are your chances? (1:17:40)

Lifestyle vs. genetics: debunking myths about dementia risk (1:20:21)

Healthy habits for a healthy brain (1:27:56)

Close relationships &amp; cognitive resilience prevent dementia (1:36:36)

Understanding amyloid plaques and Alzheimer&#39;s progression (1:49:50)

Amyloid hypothesis under scrutiny (1:59:28)

Biomarkers and cutting-edge techniques for Alzheimer&#39;s detection (2:06:08)

How to prevent cognitive decline (2:20:49)

Homocysteine, CRISPR, and the future of personalized medicine (2:23:20)

Huntington&#39;s disease and Parkinson&#39;s disease (2:29:12)

Depression and anxiety (2:44:36)

Chronic inflammatory demyelinating polyneuropathy (CIDP) &amp; Guillain-Barré (2:50:00)

Unpacking Multiple Sclerosis (MS) (2:55:146)

Outro (3:05:30)


To connect with Drs Ayesha and Dean Sherzai, you can find them on Instagram, Facebook, Twitter, and TikTok. You can also visit their website, https://thebraindocs.com/, to discover brain health resources and subscribe to their newsletter, a weekly collection of the best evidence on brain health. Make sure to check out their podcast, The Brain Health Revolution, for more audio deep dives.
If you haven’t already, make sure to listen to Drs Dean and Ayesha Sherzai’s past episodes on The Proof, where we delve into a variety of brain health topics. Find the full catalogue here.
Make sure to also check out the full show notes for supporting studies and more insights.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your fri

Keeping your brain healthy | Drs Ayesha & Dean Sherzai

Episode #262. Discover the science of getting older without getting old in this conversation with Dr Andrew Steele. From understanding what impacts your lifespan to revealing potential future scientific breakthroughs, this episode is an intriguing journey into the world of aging science.

Specifically, we discuss:

Intro (00:00)

Dr. Andrew Steele on aging (01:38)

Age-related diseases and lifespan extension (10:47)

Genetic factors, lifestyle, and gene editing for longevity (19:18)

Could gene editing help solve poor cholesterol? (27:52)

Rapamycin vs metformin for longevity (34:21)

The need for expert consensus on anti-aging interventions (39:47)

Insights on Bryan Johnson's Project Blueprint (47:50)

What are senolytic drugs? (51:24)

Yamanaka factors: is aging reversible at a cellular level? (1:05:18)

The rationale behind reversing aging and the future of interventions (1:17:42)

Lifestyle changes that slow the clock (1:25:40)

Calorie restriction and longevity (1:32:41)

Air quality, smoking, and vaping (1:44:54)

Stress, aging, and telomeres (1:51:18)

Are there biological reasons why women tend to live longer? (1:59:05)

Unpacking the buzz around HRT for men (2:04:14)

Environmental impact of extending human lifespan (2:07:23)

Outro (2:14:10)


Connect with Dr Andrew Steele on Twitter, Instagram, and Mastodon. Make sure to also head to his YouTube channel, where you’ll find videos on the ethics of prolonging lifespan and whether you can become biologically younger. Discover his book, “Ageless: The new science of getting older without getting old”, at https://andrewsteele.co.uk/ageless/, and read the free chapter on ethics here.
Enjoy, friends.
Simon

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

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